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The earliest modern study of PTH was reported by Slovik et al, new cycle cutting. In a short 12-month period, these men experienced a remarkable 2-fold increase in lumbar spine cancellous bone density as determined by quantitative computed tomography (QCT). Over the past 5 yr, 24 studies have been published, consisting of approximately 300 men and women, in which the effect of intermittent PTH on bone mass and fracture risk has been evaluated ( 44, 54).
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